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KMID : 0388019940050040001
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Korean Journal Gynecologic Oncology and Colposcopy
1994 Volume.5 No. 4 p.1 ~ p.8
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The Clinical Significance of SCC, CEA and TPA as Tumor Markers in Cervical Cancer
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Abstract
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The clinical role of tumor markers to detect the extent of tumor invasion and recurrence in cervical cancer has been debated. To evaluate the clinical significance of SCC, CEA and TPA as tumor markers in cervical cancer, we studied 744 patients
with
cervical cancer from June 1990 to May 1994. The cut-off values of SCC, CEA and TPA were 1.5 ng/ml, 4.5 ng/ml and 110 U/ml respectively.
@ES Followings were the results.
@EN 1. The serum concentration and positive rates of SCC before therapy(567 cases) were 3.0±4.3 ng/ml (18%) for stage I, 7.1±12.3 ng/ml(37.2%) for stage II 8.4±9.6 ng/ml(57.9%) for stage Ⅲ15.4±22.2 ng/ml(52.6%) for stageⅣ, and 10.3±16.2
ng/ml(46.4%0 for recurrent cancer. It was increased with advancing clinical stage from stage Ito statge Ⅲ(p<0.01)
2. The serum levels and pcsitive rate of CEA before therapy(627cases) were 3.4*4.3 ng/ml (18%) for stage I, 7.1*12.3 ng/ml(37.2%) for stage II, 8.4*9.6 ng/ml(57.9%) for stage III, 15.4*22.2 ng/ml(52.6%) for stage IV, and 10.3*16.2 ng/ml(46.6%)
for
recurrent cancer. It was increased with advancing clinical stage from stage Ito stae III(p<0.01)
3. The serum concentration and positive rate of TPA before therapy(301cases) were 51.7±53.8 U/l(9.5%) for stage I, 105.3±108.8 U/l(32.3%) for stage II, 186.3±159.8 U/l(50%) for stage Ⅲ, 191.3±106.2 U/l(63.6%)for stage Ⅳ, and 135.4±117.0
U/l(46.4%) for recurrent cancer. It ws increased with advancing clinical stage(p<0.01).
4. In 64 patients(24.2%) with lymph node invasion of 265 patients treated by operation, the mean serum levels of SCC, CEA and TPA were higher than node negative group(p<0.05).
5. The serum levels of SCC and CEA after therapy were 82.8% in sensitivity, 94.3% in specificity, 67.9% in positive predictive value, 97.4% in negative predictive value.
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KEYWORD
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